Optimizing molecular weight of octyl chitosan as drug carrier for improving tumor therapeutic efficacy

Optimizing molecular weight of octyl chitosan as drug carrier for improving tumor therapeutic efficacy

Macromolecular drug carriers have attracted much attention taking advantage of passive tumor targeting property and excellent biocompatibility. For many biomedical applications, however, the effectiveness of the carriers is insufficient, which complicate further development into clinical use. Here, we systematically investigated the effects of molecular weight (from 1KDa to 300KDa) of macromole...

ph-responsive and macrophage evading low molecular weight chitosan coated nanoparticles for tumor-specific drug delivery

TAT-LHRH conjugated low molecular weight chitosan as a gene carrier specific for hepatocellular carcinoma cells

To develop a chitosan-based nonviral gene carrier capable of delivering genes specifically into hepatoma cells, a bifunctional peptide composed of the TAT (transactivator of transcription) peptide and luteinizing hormone-releasing hormone (LHRH) was conjugated with low molecular weight chitosan, resulting in a TAT-LHRH-chitosan conjugate (TLC). TLC/DNA nanoparticles (TLCDNPs) were characterized...

Environmental friendly carrier material for nifedipine as hypertension drug

Nifedipine is a hypertension drug must be consumed three times a day due to its low oral bioavailability. One way of developing a controlled drug delivery system is making nifedipine microcapsules by using environmentally friendly polymers of polylactic acid and polycaprolactone via the evaporation method using oil-in-water solvents. Polylactic acid and polycaprolactone can be said to be enviro...

Nano-structured Chitosan Self-aggregates as a Drug Delivery Carrier

Colloidal delivery systems including polymeric selfaggregates have been widely investigated to date, as these formulations may reduce unwanted side effects and may improve the therapeutic effects. Various characteristics of self-aggregates prepared from deoxycholic acid-modified chitosan were investigated by fluorescence spectroscopic and dynamic light scattering methods, and found to be contro...